Toluene

CAS

Purity

CHARACTER

toluene is a colorless, aromatic liquid, chemical formula C7H8, molecular weight 92.14. It is an important chemical raw material and solvent, widely used in coatings, paints, inks, resins and dyes and other industrial fields. Toluene has excellent solubility and volatility, can be used to dilute and dissolve a variety of substances, improve the fluidity and gloss of the product. In addition, toluene is also used in the production of organic chemicals such as phenol and trinitrotoluene, as well as as gasoline additives to improve the octane number and anti-knock performance of gasoline. In the fields of medicine, pesticide and dye synthesis, toluene also plays an important role and is one of the indispensable chemical raw materials.

APPLICATIONS

1, widely used as organic solvents and synthetic medicine, coatings, resins, dyes, explosives and pesticides, such as raw materials, used as chromatographic analysis of standard substances and analytical reagents.

2, toluene can be used as a raw material for the production of benzene and many other chemical products. Such as paint, varnish, lacquer, adhesive and ink manufacturing industry and the formulation of the thinner, resin solvent; Chemical and manufacturing solvents; In particular, the extraction and degreasing two processes are most suitable. It is also a raw material for chemical synthesis. It can also be used as a blending component for gasoline to increase octane number and as a solvent for coatings, inks and nitrocellulose. A series of intermediates produced by toluene are called toluene-based intermediates. Chemical industry is mainly used to produce benzene and xylene, its downstream main products are nitrotoluene, benzoic acid, benzyl chloride, m-cresol, toluene diisocyanate, etc., can also produce many pesticides and pharmaceutical intermediates. In addition, toluene has excellent organic solubility and is a widely used organic solvent. Toluene is prone to chlorination and generates benzene-chloromethane or phenyltrichloromethane, which are all good solvents in industry. It is also easy to nitrate and generate p-nitrotoluene or o-nitrotoluene, which are all raw materials for dyes. It is also easy to sulfonate and generate o-toluenesulfonic acid or p-toluenesulfonic acid, which are raw materials for dyes or sugar production. The vapor of toluene is mixed with air to form an explosive substance, so it can make a Tester explosive.

3. Plant ingredient leaching agent. It is used in large quantities as a solvent and high-octane gasoline additive.

4, used as an analytical reagent, such as solvent, extraction separation agent, chromatographic analysis reagent. Also used as a cleaning agent, and used in dyes, spices, benzoic acid and other organic synthesis.

5, used for blending gasoline composition and as the production of toluene derivatives, explosives, dye intermediates, drugs and other main raw materials.

INDICATORS

ABILITIES

1. Packing: barreled, scattered water
2. Logistics: car transportation, shipping
3. Payment request: EXW/FOB/FCA/CFR only accepted

HONORARY

Chemical properties

Toluene is very stable under normal conditions, but it can react violently with acid or oxidant. Its chemical properties are similar to phenol and benzene, and its reactivity is between the two. Toluene corrodes plastics and must be stored in glass containers. In an oxidation reaction (e. g. with hot alkaline potassium permanganate solution), toluene can be oxidized to benzoic acid by benzyl alcohol, benzaldehyde and finally. Toluene is mainly capable of free radical substitution, electrophilic substitution and free radical addition reactions. Nucleophilic reactions occur less often. Toluene can undergo radical substitution reactions with certain reactants (e. g., bromine) on the methyl group under heat or light irradiation.

Use

2 and toluene can be used as raw materials for the production of benzene and many other chemical products. Such as paint, varnish, lacquer, adhesive and ink manufacturing industry and the formulation of the thinner, resin solvent; Chemical and manufacturing solvents; In particular, the extraction and degreasing two processes are most suitable. It is also a raw material for chemical synthesis. It can also be used as a blending component for gasoline to increase octane number and as a solvent for coatings, inks and nitrocellulose. A series of intermediates produced by toluene are called toluene-based intermediates. Chemical industry is mainly used to produce benzene and xylene, its downstream main products are nitrotoluene, benzoic acid, benzyl chloride, m-cresol, toluene diisocyanate, etc., can also produce many pesticides and pharmaceutical intermediates. In addition, toluene has excellent organic solubility and is a widely used organic solvent. Toluene is prone to chlorination and generates benzene-chloromethane or phenyltrichloromethane, which are all good solvents in industry. It is also easy to nitrate and generate p-nitrotoluene or o-nitrotoluene, which are raw materials for dyes. It is also easy to sulfonate and generate o-toluenesulfonic acid or p-toluenesulfonic acid, which is the raw material for dyes or sugar essence. The vapor of toluene is mixed with air to form an explosive substance, so it can make a Tester explosive.

3. Plant ingredient leaching agent. It is used in large quantities as a solvent and high-octane gasoline additive.

4, used as analytical reagent, such as solvent, extraction separation agent, chromatographic analysis reagent. Also used as a cleaning agent, and used in dyes, spices, benzoic acid and other organic synthesis.

5, used for blending gasoline composition and as the production of toluene derivatives, explosives, dye intermediates, drugs, such as the main raw materials.

Operation Disposal and Storage

Operation precautions: airtight operation, strengthen ventilation. Operators must be specially trained and strictly abide by the operating procedures. It is recommended that the operator wear self-priming filtering gas mask (half mask), chemical safety goggles, anti-poison penetration overalls and rubber oil-resistant gloves. Keep away from fire and heat sources. Smoking is strictly prohibited in the workplace. Use explosion-proof ventilation systems and equipment. Prevent vapor leakage into the workplace air. Avoid contact with oxidizing agents. When filling, the flow rate should be controlled, and there is a grounding device to prevent static accumulation. Handle and unload lightly to prevent damage to packaging and containers. Equipped with corresponding types and quantities of fire-fighting equipment and leakage emergency treatment equipment. Empty containers may leave harmful substances.

Precautions for storage: Store in a cool and ventilated warehouse. Keep away from fire and heat source. The warehouse temperature should not exceed 30 ℃. Keep container sealed. Should be stored separately from the oxidant, do not mix storage. Explosion-proof lighting and ventilation facilities shall be adopted. It is forbidden to use mechanical equipment and tools that are easy to produce sparks. The storage area should be equipped with leakage emergency treatment equipment and suitable containment materials.

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Chemical Safety Data Sheet MSDS / SDS

Toluene

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: Toluene
CBnumber: CB4233905
CAS: 108-88-3
EINECS Number: 203-625-9
Synonyms: toluene,Tol

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 400-158-6606

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P405 Store locked up.

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

Hazard statements

H373 May cause damage to organs through prolonged or repeated exposure

H361 Suspected of damaging fertility or the unborn child

H336 May cause drowsiness or dizziness

H333 May be harmful if inhaled

H315 Causes skin irritation

H304 May be fatal if swallowed and enters airways

H302 Harmful if swallowed

H225 Highly Flammable liquid and vapour

Disposal

WARNING.Cancer - https://oehha.ca.gov/proposition-65/chemicals/toluene

SECTION 3: Composition/information on ingredients

Substance

Product name: Toluene
Synonyms: toluene,Tol
CAS: 108-88-3
EC number: 203-625-9
MF: C7H8
MW: 92.14

SECTION 4: First aid measures

Description of first aid measures

General advice

Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Call in physician.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.

In case of eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

If swallowed

After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Pulmonary failure possible after aspiration of vomit. Call a physician immediately.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Carbon dioxide (CO2) Foam Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Combustible.

Pay attention to flashback.

Vapors are heavier than air and may spread along floors.

Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.

Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

Further information

Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.

Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.

Environmental precautions

Do not let product enter drains. Risk of explosion.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up carefully with liquid-absorbent material (e.g.

Chemizorb?). Dispose of properly. Clean up affected area.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and sources of ignition.

Handle and store under inert gas.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate

government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact Material: Viton?

Minimum layer thickness: 0,7 mm Break through time: 480 min

Material tested:Vitoject? (KCL 890 / Aldrich Z677698, Size M)

Splash contact Material: Viton?

Minimum layer thickness: 0,7 mm Break through time: 480 min

Material tested:Vitoject? (KCL 890 / Aldrich Z677698, Size M)

Body Protection

Flame retardant antistatic protective clothing.

Respiratory protection

Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains. Risk of explosion.

Exposure limits

TLV-TWA 100 ppm (～375 mg/m³) (ACGIH, NIOSH, and MSHA), 200 ppm (～750 mg/ m3) OSHA; ceiling 300 ppm, peak 500 ppm/ 15 min (OSHA); STEL 150 ppm (ACGIH).

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearanceliquid
Odourbenzene-like
Odour Threshold0,2 ppm
pHNot applicable
Melting point/freezing pointMelting point/range: -93 °C
Initial boiling point and boiling range110 - 111 °C
Flash point4,0 °C - c.c.
Evaporation rateNo data available
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limitsUpper explosion limit: 7,1 %(V) Lower explosion limit: 1,2 %(V)
Vapour pressure30,88 hPa at 21,1 °C
Vapour density3,18
Relative density0.865～0.870(20/20℃)(Ph.Eur.)
Water solubility0,58 g/l at 25 °C - partly soluble
Partition coefficient: n-octanol/waterlog Pow: 2,73 at 20 °C - Bioaccumulation is not expected.
Autoignition temperature535,0 °C
Decomposition temperatureNo data available
ViscosityViscosity, kinematic: No data available Viscosity, dynamic: 0,56 mPa.s at 25 °C
Explosive propertiesNo data available
Oxidizing propertiesNo data available
Henry's Law Constant1.05 at 40 °C, 1.68 at 50 °C, 2.62 at 60 °C, 3.15 at 70 °C, 3.97 at 80 °C (headspace-GC, Vane et al., 2001)

Other safety information

Conductivity < 0,01 μS/cm

Surface tension 27,73 mN/m at 0,516g/l at 25 °C

Relative vapor density

3,18

SECTION 10: Stability and reactivity

Reactivity

Vapors may form explosive mixture with air. Vapors may form explosive mixture with air.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) . The product is chemically stable under standard ambient conditions (room temperature) .

Possibility of hazardous reactions

Risk of explosion with: fuming sulfuric acid Nitric acid

silver perchlorates nitrogen dioxide

nonmetallic halides acetic acid

halogen-halogen compounds uranium hexafluoride organic nitro compounds

Violent reactions possible with: Strong acids

Strong oxidizing agents sulfur

with Heat.

Conditions to avoid

Warming. Warming.

Incompatible materials

rubber, various plastics

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - male - 5.580 mg/kg
(Tested according to Directive 92/69/EEC.)
LC50 Inhalation - Rat - male and female - 4 h - 25,7 mg/l (OECD Test Guideline 403)
LD50 Dermal - Rabbit - > 5.000 mg/kg Remarks: (ECHA)

Skin corrosion/irritation

Skin - Rabbit
Result: irritating - 4 h Remarks: (ECHA)

Serious eye damage/eye irritation

Eyes - Rabbit
Result: slight irritation (OECD Test Guideline 405)

Respiratory or skin sensitization

(Regulation (EC) No. 440/2008, Annex, B.6)

Germ cell mutagenicity

Test Type: In vitro mammalian cell gene mutation test Test system: Mouse lymphoma test
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 476
Result: negative
Test Type: Ames test
Test system: S. typhimurium
Metabolic activation: with and without metabolic activation
Method: Mutagenicity (Salmonella typhimurium - reverse mutation assay) Result: negative
Test Type: Chromosome aberration test Species: Rat
Cell type: Bone marrow Application Route: i.p.
Result: negative Remarks: (ECHA)

Carcinogenicity

No data available

Reproductive toxicity

Suspected of damaging the unborn child.

Specific target organ toxicity - single exposure

May cause drowsiness or dizziness. - Central nervous system

Specific target organ toxicity - repeated exposure

May cause damage to organs through prolonged or repeated exposure. - Central nervous system

Aspiration hazard

Aspiration hazard, Aspiration may cause pulmonary edema and pneumonitis.

Toxicity

LD50 orally in rats: 7.53 g/kg (Smyth)

SECTION 12: Ecological information

Toxicity

Toxicity to fish

flow-through test LC50 - Oncorhynchus kisutch (coho salmon) - 5,5 mg/l - 96 h

Remarks: (ECHA)

Toxicity to daphnia and other aquatic invertebrates

EC50 - Ceriodaphnia dubia (water flea) - 3,78 mg/l - 48 h (US-EPA)

Toxicity to bacteria

static test EC50 - Bacteria - 84 mg/l - 24 h

Remarks: (ECHA)

Persistence and degradability

Biodegradability aerobic - Exposure time 20 d

Result: 86 % - Readily biodegradable. Remarks: (IUCLID)

Bioaccumulative potential

Bioaccumulation Leuciscus idus (Golden orfe) - 3 d

- 0,05 mg/l(Toluene)

Bioconcentration factor (BCF): 90

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Violent reaction with mixtures of nitric and sulfuric acid.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.

SECTION 14: Transport information

UN number

ADR/RID: 1294 IMDG: 1294

UN proper shipping name

ADR/RID: TOLUENE IMDG: TOLUENE IATA: Toluene

Transport hazard class(es)

ADR/RID: 3 IMDG: 3 IATA: 3

Packaging group

ADR/RID: II IMDG: II IATA: II

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

EC Inventory:Listed.

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Depending on the degree of exposure, periodic medical examination is suggested.Use of alcoholic beverages enhances the harmful effect.

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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