MIBK (4-Methyl -2-pentanone)

CAS

Purity

CHARACTER

methyl isobutyl ketone (MIBK), chemical formula C6H12O, is a colorless transparent liquid with a special smell and 100.16 molecular weight. It has good solubility and volatility, can be miscible with a variety of organic solvents, slightly soluble in water. Methyl isobutyl ketone is an important organic solvent and chemical raw material, which is widely used in coatings, inks, resins, rubber, pesticides and pharmaceuticals. In the paint and ink industry, MIBK is used as a solvent to improve the fluidity and gloss of the product; in the resin and rubber industry, it is a raw material for the synthesis of a variety of polymer materials; in the pesticide and pharmaceutical industry, MIBK is used for the synthesis of a variety of active ingredients. As a multifunctional chemical raw material, methyl isobutyl ketone plays an important role in industrial production.

APPLICATIONS

(1) As a solvent: MIBK is used as a solvent in the production of coatings, inks and adhesives. Due to its good solubility and moderate volatilization rate, it helps to improve the fluidity and coating performance of the coating and improve the appearance of the coating And smoothness. At the same time, it can also be used as an extraction solvent and a crystallization solvent, for example, in the production process of pharmaceutical and pesticide intermediates.

(2) Chemical reaction medium: MIBK is often used as a medium for chemical reactions, especially in organic synthesis. For example, in the production of pesticides, pharmaceutical intermediates and fragrances, MIBK is often used as a solvent or reaction medium to help improve the reaction rate and product yield.

(3) Rubber and plastics industry applications: In the rubber and plastics industry, MIBK is used to manufacture rubber antioxidants and plasticizers, which can effectively improve the anti-aging properties of rubber and the flexibility of plastics, thereby extending the service life of products. In addition, MIBK is used as a synthetic solvent and additive for plastics and rubber.

(4) Manufacturing of other fine chemicals: MIBK can also be used to manufacture other fine chemicals, such as dyes, pigments, lubricating oil dewaxing agents, etc., and plays a key role in the production of these products.

ABILITIES

1. Packing: barreled, scattered water
2. Logistics: car transportation, shipping
3. Payment request: EXW/FOB/FCA/CFR only accepted

HONORARY

Chinese name	4-methyl -2-pentanone
English Name	4-Methyl-2-pentanone
Alias	Six carbon ketone methyl ketone isohexanone methyl isopropyl ketone methyl isobutyl ketone isopropyl acetone methyl isobutyl ketone isobutyl methyl ketone methyl isobutyl ketone 4-Methylpentanone [2] 4-Methyl -2-pentanone 2-methyl -4-pentanone
English alias	MIBK Hexone Isopropylacetone 4-Methyl-2-pentanone 4-methylpentan-2-one Methyl isobuty ketone Methyl isobutyl keton Isobutyl methyl ketone Methyl isobutyl ketone MethylIsobutylKetoneAcs Methyl-Iso-ButylKetoneGr 4-METHYL-2-PENTANONE, FOR GC METHYL ISOBUTYL KETONE GC STANDARD Methyl-Iso-ButylKetone(Iso-ButylMethylKetone)
CAS	108-10-1
EINECS	203-550-1
Chemical formula	C6H12O
molecular weight	100.16
InChI	InChI=1/C6H12O/c1-5(2)4-6(3)7/h5H,4H2,1-3H3
Density	0.801 g/mL at 25°C (lit.)
melting point	-80°C (lit.)
boiling point	117-118°C
Flash Point	56°F
water solubility	17 g/L (20 °C)
Vapor pressure	15mm Hg ( 20 °C)
steam density	3.5 (vs air)
JECFA Number	301
solubility	Water: soluble 20g/L
refractive index	n20/D 1.395(lit.)
Storage conditions	Store at +5°C to +30°C.
Appearance	Solid
Color	APHA: ≤15
Smell	Pleasant; mild, characteristic; sharp; non-residual; ketonic.
Maximum wavelength (λmax)	['λ: 335 nm Amax: 1.00', , 'λ: 340 nm Amax: 0.50', , 'λ: 360 nm Amax: 0.15', , 'λ: 38
Merck	14,5207
BRN	605399
explosion limit value	1.2-8%, 93°F
Exposure Limits	TLV-TWA 205 mg/m3 (50 ppm); STEL 300mg/m3 (75 ppm) (ACGIH); IDLH 3000 ppm(NIOSH).
physicochemical properties	This product is a colorless transparent liquid with camphor smell, m.p.-80 ℃, B .p.117~118 ℃,n20D 1.3960, relative density 0.801,f.p.56 ℉(13 ℃), almost insoluble in water, but can form azeotrope with water, its boiling point is 87.9 ℃, water content is 24.3, ketone content is 75.7, can be miscible with phenol, aldehyde, ether, benzene and other organic solvents. This product is toxic, the vapor irritates the eyes and respiratory tract.
Dangerous Goods Signs	F-Inflammable Materials Xn-Hazardous Materials T-Toxic Materials
Risk Terms	R11-Highly flammable. , R20-Harmful if inhaled. , R36/37-Irritating to eyes and respiratory system. -R66-Long-term exposure may cause skin chapped. R39/23/24/25 - R23/ 24/25-Toxic by inhalation, skin contact and swallowing.
Security terminology	S9-Keep container in a well-ventilated place. , S16-Keep away from ignition sources. , S29-Do not pour into the drain. -S45-In case of accident or feeling unwell, seek medical attention (if possible, show their label). , S36/37-Wear appropriate protective clothing and gloves. -S7-Keep container sealed.
Dangerous Goods Transport Number	UN 1245 3/PG 2
WGK Germany	1
RTECS	SA9275000
TSCA	Yes
Customs number	2914 13 00
Hazard Class	3
Packing Group	II
Upstream raw materials	acetone hydrogen
Downstream Products	4-methyl -2-pentanone antioxidant 4020 azobisisoheptanitrile

Methyl isobutyl ketone -Properties

Colorless transparent liquid. Aromatic ketone smell. With ethanol, ether, acetone, benzene and other miscible, soluble in water (1-91%). Its vapor and air form an explosive mixture, which can cause combustion and explosion when exposed to open flame and high heat. Can react strongly with oxidants. In case of high heat, the internal pressure of the container increases, and there is a risk of cracking and explosion. Dissolves certain plastics, resins and rubbers.

Methyl isobutyl ketone -preparation

By industrial methyl isobutyl ketone distillation can be.

Methyl isobutyl ketone -Application

is an effective separating agent for some inorganic salts, separating plutonium from uranium, niobium from tantalum, and zirconium from hafnium. It can also be used as an anticoagulant and diluent for vinyl resins. Is a good medium boiling point solvent. Used as mineral dressing agent, oil dewaxing solvent, color film coupler, also used as tetracycline and pyrethroids and DDT solvent. It is also used in the organic synthesis industry.

Methyl isobutyl ketone -Safety

Inhalation of people can cause inhibition and anesthesia of the central nervous system. When the inhalation concentration is high, it can stimulate the respiratory tract and cause nausea, vomiting, loss of appetite, abdominal pain, etc. The staff shall be well protected and the workplace shall be ventilated. Store in a cool, ventilated warehouse. Keep away from fire and heat source. Prevent direct sunlight. Keep container sealed. Should be stored separately from the oxidizer.

Methyl isobutyl ketone -Introduction

4-methyl-2-pentanone is an organic compound. The following is about its nature, use, preparation and safety information:

Properties:
Appearance: 4-methyl-2-pentanone is a colorless liquid with a water-like odor.
-Density: Its density is about 0.812 g/mL.
-Solubility: It is soluble in ethanol, ether and acetone and other common organic solvents, but insoluble in water.

Uses:
4 -methyl -2-pentanone can be used as organic synthesis reaction solvent, especially in plant extract extraction and separation of widely used.

Preparation: There are many ways to prepare
4-methyl-2-pentanone. One of the common methods is to obtain from hexanone (2-pentanone) by methyl saturation reaction. This reaction requires the use of a methylating agent such as methyl magnesium bromide (MeMgBr) or methyl sodium iodide (MeI). By this method, a methyl group can be added to the carbon skeleton of the 2-pentanone molecule to give 4-methyl-2-pentanone.

Safety Information:- 4-methyl-2-pentanone
is toxic to humans, and exposure or inhalation may cause irritation and injury. Direct contact with the skin and eyes, as well as inhalation of vapors of the substance, should be avoided.
-Wear appropriate personal protective equipment such as gloves, goggles and respirators when used. Avoid fire and high temperature during use and storage. -In the event of a
leak, immediately take appropriate emergency measures and ensure good ventilation.
before use, please carefully read and follow the product safety guidelines and relevant regulations.

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Chemical Safety Data Sheet MSDS / SDS

4-Methyl-2-pentanone

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: 4-Methyl-2-pentanone
CBnumber: CB8691781
CAS: 108-10-1
EINECS Number: 203-550-1
Synonyms: MIBK,Methyl Isobutyl Ketone

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P311 Call a POISON CENTER or doctor/physician.

P370+P378 In case of fire: Use … for extinction.

P403+P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

Hazard statements

H225 Highly Flammable liquid and vapour

H319 Causes serious eye irritation

H332 Harmful if inhaled

H335 May cause respiratory irritation

H370 Causes damage to organs

Disposal

WARNING.Cancer - https://oehha.ca.gov/proposition-65/chemicals/methyl-isobutyl-ketone-mibk

SECTION 3: Composition/information on ingredients

Substance

Product name: 4-Methyl-2-pentanone
Synonyms: MIBK,Methyl Isobutyl Ketone
CAS: 108-10-1
EC number: 203-550-1
MF: C6H12O
MW: 100.16

SECTION 4: First aid measures

Description of first aid measures

General advice

Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.

In case of eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

If swallowed

After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Carbon dioxide (CO2) Foam Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

Special hazards arising from the substance or mixture

Carbon oxides Combustible.

Pay attention to flashback.

Vapors are heavier than air and may spread along floors.

Development of hazardous combustion gases or vapours possible in the event of fire. Forms explosive mixtures with air at ambient temperatures.

Advice for firefighters

In the event of fire, wear self-contained breathing apparatus.

Further information

Remove container from danger zone and cool with water. Prevent fire extinguishing water from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Keep away from heat and sources of ignition.

Evacuate the danger area, observe emergency procedures, consult an expert. For personal protection see section 8.

Environmental precautions

Do not let product enter drains. Risk of explosion.

Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb? ). Dispose of properly. Clean up affected area.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Advice on protection against fire and explosion

Keep away from open flames, hot surfaces and sources of ignition.Take precautionary measures against static discharge.

Hygiene measures

Change contaminated clothing. Preventive skin protection recommended. Wash hands after working with substance.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Keep away from heat and

sources of ignition.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Splash contact Material: butyl-rubber

Minimum layer thickness: 0,7 mm Break through time: 240 min Material tested:Butoject? (KCL 898)

Body Protection

Flame retardant antistatic protective clothing.

Respiratory protection

Recommended Filter type: Filter A (acc. to DIN 3181) for vapours of organic compounds

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

Control of environmental exposure

Do not let product enter drains. Risk of explosion.

Exposure limits

TLV-TWA 205 mg/m³ (50 ppm); STEL 300 mg/m³ (75 ppm) (ACGIH); IDLH 3000 ppm (NIOSH).

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearancecolorless liquid
Odourcharacteristic
Odour Threshold0,1 ppm
pHat 20 °C neutral
Melting point/freezing pointMelting point/range: -80 °C - lit.
Initial boiling point and boiling range117 - 118 °C
Flash point14 °C - closed cup - DIN 51755 Part 1
Evaporation rateNo data available
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limitsUpper explosion limit: 8 %(V) Lower explosion limit: 1,2 %(V)
Vapour pressure20 hPa at 20 °C
Vapour density3,46 - (Air = 1.0)
Relative density0,801 g/cm3 at 25 °C - lit. No data available
Water solubility14,1 g/l at 20 °C - OECD Test Guideline 105- completely soluble
Partition coefficient: n-octanol/waterlog Pow: 1,9 - Bioaccumulation is not expected.
Autoignition temperatureNo data available
Decomposition temperatureNo data available
ViscosityViscosity, kinematic: No data available Viscosity, dynamic: 0,59 mPa.s at 20 °C
Explosive propertiesNo data available
Oxidizing propertiesNo data available
Henry's Law Constant2.56 at 25 °C (batch stripping method-GC, Kim et al., 2000)
λmaxλ: 335 nm Amax: 1.00
λ: 340 nm Amax: 0.50
λ: 360 nm Amax: 0.15
λ: 380 nm Amax: 0.02
λ: 400 nm Amax: 0.01

Other safety information

Surface tension 23,6 mN/m at 20 °C

Relative vapor density

3,46 - (Air = 1.0)

SECTION 10: Stability and reactivity

Reactivity

Stable under recommended storage conditions. Vapors may form explosive mixture with air.

Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) . Stable under recommended storage conditions.

Possibility of hazardous reactions

No data available

Conditions to avoid

Heat, flames and sparks. Extremes of temperature and direct sunlight. May form peroxides of unknown stability.

Warming.

Incompatible materials

rubber, various plastics, Copper

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - 2.080 mg/kg
(OECD Test Guideline 401)
LC50 Inhalation - Rat - male - 4 h - 11,6 mg/l (OECD Test Guideline 403)
Dermal

Skin corrosion/irritation

Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)

Serious eye damage/eye irritation

Eyes - Rabbit
Result: Causes serious eye irritation. - 72 h (OECD Test Guideline 405)
(Regulation (EC) No 1272/2008, Annex VI)

Respiratory or skin sensitization

(OECD Test Guideline 406)

Germ cell mutagenicity

Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 471
Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: rat hepatocytes
Metabolic activation: without metabolic activation Method: OECD Test Guideline 473
Result: negative
Test Type: In vitro mammalian cell gene mutation test Test system: mouse lymphoma cells
Metabolic activation: with and without metabolic activation Method: OECD Test Guideline 476
Result: negative
Test Type: Micronucleus test Species: Mouse
Cell type: Bone marrow Application Route: Intraperitoneal Method: OECD Test Guideline 474 Result: negative

Carcinogenicity

No data available

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

May cause respiratory irritation. - Respiratory system

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

Toxicity

LD50 orally in rats: 2.08 g/kg (Smyth)

SECTION 12: Ecological information

Toxicity

Toxicity to fish

static test LC50 - Danio rerio (zebra fish) - > 179 mg/l - 96 h (OECD Test Guideline 203)

Toxicity to daphnia and other aquatic invertebrates

static test EC50 - Daphnia magna (Water flea) - > 200 mg/l - 48 h (OECD Test Guideline 202)

Persistence and degradability

Biodegradability aerobic - Exposure time 28 d

Result: 83 % - Readily biodegradable. (OECD Test Guideline 301F)

Theoretical oxygen demand

2.720 mg/g Remarks: (Lit.)

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

Incompatibilities

Able to form unstable and explosive peroxides on contact with air. Reacts violently with strong oxidizers, potassium tert-butoxide; strong acids; aliphatic amines; reducing agents

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration.

SECTION 14: Transport information

UN number

ADR/RID: 1245 IMDG: 1245 IATA: 1245

UN proper shipping name

	ADR/RID: METHYL ISOBUTYL KETONE IMDG: METHYL ISOBUTYL KETONE
IATA: Methyl isobutyl ketone
14.3	Transport hazard class(es) ADR/RID: 3 IMDG: 3	IATA: 3
14.4	Packaging group ADR/RID: II IMDG: II	IATA: II
14.5	Environmental hazards ADR/RID: no IMDG Marine pollutant: no	IATA: no
14.6	Special precautions for user No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

EC Inventory:Listed.

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

Check for peroxides prior to distillation; eliminate if found.

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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