Butanone

CAS

Purity

CHARACTER

butanone, also known as methyl ethyl ketone, is a colorless and transparent liquid with a unique aromatic odor. Its boiling point is about 79.6°C and its flash point is -7.2°C. It is an important organic solvent and chemical raw material. It is widely used in coatings, inks, resins, adhesives, dyes and other industrial fields. As a solvent, it can effectively improve the solubility and drying speed of products. At the same time, butanone is also a key intermediate in the synthesis of certain drugs, spices and pesticides. Its chemical properties are active and easy to react with other compounds, such as the reduction, addition and condensation of ketones. Because of its excellent solubility and volatility, butanone is often used as a solvent for organic synthesis and chemical reactions in the laboratory. Pay attention to its flammable and explosive properties and take appropriate safety measures when using it.

APPLICATIONS

(1) butanone has a strong dissolving ability, can dissolve a variety of organic and inorganic substances, is widely used as a solvent. It plays a key role in the coatings industry, especially in polyurethane coatings, nitro coatings and acrylic coatings. The rapid volatility of butanone can accelerate the drying process of coatings, thereby improving production efficiency.

(2) butanone is an important intermediate in the manufacture of a variety of chemical products. For example, it can be used in the synthesis of methyl ethyl ketoxime (MEKO), an important preservative and antioxidant. In addition, butanone can also be used in the synthesis of drugs, spices and pesticides.

(3) In the electronics industry, butanone is used as a cleaning agent for cleaning and removing grease and dirt on electronic devices due to its high volatility and excellent solubility. Especially in the process of manufacturing semiconductors and electronic components, butanone is an ideal cleaning solvent.

(4) Methyl ethyl ketone is widely used in the production of adhesives and sealants, especially in the manufacture of synthetic rubber, vinyl resins and other polymer-based materials. Its excellent dissolution properties and fast drying characteristics make butanone irreplaceable in these applications.

(5) Butanone can also be used as a reagent for the determination of cadmium, copper and mercury, a standard substance for chromatographic analysis, and a solvent for semiconductor lithography, which further reflects its important value in the field of chemical analysis and semiconductor manufacturing.

ABILITIES

1. Packing: barreled, scattered water
2. Logistics: car transportation, shipping
3. Payment request: EXW/FOB/FCA/CFR only accepted

HONORARY

Physical Properties

Melting point:-85.9 ℃

Density: 0.806 g/cm 3

Boiling point: 79.6 ℃

Saturated vapor pressure: 9.49kPa(20 ℃)

Combustion heat: 2441.8kJ/mol

Critical temperature: 260 ℃

Critical pressure: 4.40MPa

Octanol/water partition coefficient: 0.29

Flash point:-9 ℃(CC)

Ignition temperature: 404 ℃

Explosion limit (V/V ):11.4%

Explosive limit (V/V ):1.7%

Appearance and properties: colorless liquid, like acetone odor.

Solubility: soluble in water, ethanol, ether, miscible in oil.

Chemical Properties

methyl ethyl ketone has a carbonyl group and an active hydrogen adjacent to the carbonyl group, and thus various reactions easily occur. Condensation occurs on heating with hydrochloric acid or sodium hydroxide to give 3,4-dimethyl-3-hexen-2-one or 3-methyl-3-hepten-5-one. When exposed to sunlight for a long time, ethane, acetic acid, condensation products, etc. Diacetyl is generated upon oxidation with nitric acid. When oxidized with a strong oxidant such as chromic acid, acetic acid is produced. Butanone is relatively stable to heat, and thermal cracking at higher temperatures generates ketene or methyl ketene. When condensed with an aliphatic or aromatic aldehyde, high-molecular weight ketones, cyclic compounds, ketals, resins, and the like are produced. For example, condensation with formaldehyde in the presence of sodium hydroxide first produces 2-methyl-l-butanol-3-one, followed by dehydration to methyl isopropenyl ketone.

Resinification occurs when the is exposed to sunlight or ultraviolet light. Condensation with phenol yields 2,2-bis (4-hydroxyphenyl) butane. It reacts with an aliphatic ester in the presence of a basic catalyst to form a β-diketone. Acylation occurs in the presence of an acid catalyst with an anhydride to form a β-diketone. It reacts with hydrogen cyanide to form cyanohydrin. Reaction with ammonia yields a ketopiperidine derivative. The α-hydrogen atom of butanone is easily replaced by halogen to give various halogenated ketones, for example, 3-chloro-2-butanone, when reacted with chlorine. The reaction with 2,4-dinitrophenylhydrazine produces a yellow 2,4-dinitrophenylhydrazone.

molecular structure data

Molar refractive index: 20.60

Molar volume (cm 3 /mol):91.6

Iso tension specific volume (90.2K):196.3

Surface tension (dyne/cm):21.0

Polarimetric (10 3 -24cm ):8.17

Computational Chemistry Data

Hydrophobic parameter calculation reference value (XlogP):0

Hydrogen bond donor quantity: 0

Hydrogen bond acceptor number: 1

Rotatable chemical bond number: 1

Tautomers number: 3

Topological Molecular Polar Surface Area: 17.1

Heavy atom number: 5

Surface charge: 0

Complexity: 38.9

Isotopic atomic number: 0

Determination of atomic stereocenter number: 0

Uncertain atomic stereocenter number: 0

Determine the chemical bond stereocenter number: 0

Uncertain chemical bond stereocenter number: 0

Covalent bond unit number: 1

ecological data

1. Eco-toxicity

LC50: 1690~5640mg/L(96h)(bluegill sunfish);3200mg/L(96h)(black-headed dull fish, pH 7.5);1950mg/L(24h)(Artemia salina);<520mg/L(48h)(Daphnia, pH 8);918~3349mg/L(48h)(Daphnia, pH 7.21)

50 of IC :110~4300mg/L(72h)(algae).

2. Biodegradability

Aerobic biodegradation: 24~168h

Anaerobic biodegradation: 96~672h

3. Non-biodegradable

Water photooxidation half-life: 1.80 × 10 4 ~7.10 × 10 5 h

Air photooxidation half-life: 64.2~642h

Primary hydrolysis half-life:>50a h

Use

1, used as acetate, acrylic resin, alkyd resin, paint, ink and other solvents, dye binder, lubricant dewaxing agent, vulcanization accelerator and

2, used for the determination of cadmium, copper and mercury reagents, chromatographic analysis of standard substances and semiconductor lithography solvent

3, GB 2760-96 provisions for the use of edible spices. Mainly used for the preparation of cheese, coffee and banana flavor. It can also be used as an extraction solvent.

4, mainly used as a solvent, such as for lubricating oil dewaxing, coating industry and a variety of resin solvents, vegetable oil extraction process and refining process of azeotropic distillation, its advantage is strong solubility, low volatility than acetone, medium boiling point ketone solvent. Butanone is also the preparation of pharmaceuticals, dyes, detergents, fragrances, antioxidants and some catalysts are intermediates, synthetic anti-peeling agent methyl ethyl ketone oxime, polymerization catalyst methyl ethyl ketone peroxide, corrosion inhibitor methyl pentyne alcohol, etc., in the electronics industry used as integrated circuit lithography developer.

5, is the preparation of acaricide pyrazine raw materials.

Precautions

Health Hazards

Invasion route: inhalation, ingestion, percutaneous absorption.

health hazards: irritating to eyes, nose, throat and mucous membrane. Prolonged exposure can cause dermatitis. This product is often with 2-hexanone-mixed application, can strengthen 2-hexanone caused by peripheral neuropathy phenomenon, but alone exposure to butanone did not find a peripheral neuropathy phenomenon.

Explosion hazard: The product is flammable and irritating.

Toxicological Data and Environmental Behavior

Toxicity: belongs to low toxicity category.

irritation: rabbit by eye: 80mg, causing irritation. Percutaneous open stimulation test in rabbits: 13780µg(24 hours), mild prick.

Mutagenicity: Sex chromosome deletion and non-disjunction: Saccharomyces cerevisiae 33,800 ppm.

Reproductive toxicity: rats inhaled the lowest toxic concentration (TCLo):3000ppm(7 hours),(pregnant 6-15 days), causing craniofacial (including nose, tongue) dysplasia, genitourinary system dysplasia, causing coagulation abnormalities.

hazardous characteristics: flammable, its vapor and air can form an explosive mixture. In case of open flame, high heat or contact with oxidant, there is a danger of combustion and explosion. Its vapor is heavier than air and can spread to a considerable distance at a lower level, causing backburning in case of an open flame.

Combustion (decomposition) products: carbon monoxide, carbon dioxide.

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Chemical Safety Data Sheet MSDS / SDS

2-Butanone

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: 2-Butanone
CBnumber: CB4854386
CAS: 78-93-3
EINECS Number: 201-159-0
Synonyms: 2-butanone,MEK

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P405 Store locked up.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

Hazard statements

H336 May cause drowsiness or dizziness

H319 Causes serious eye irritation

H225 Highly Flammable liquid and vapour

SECTION 3: Composition/information on ingredients

Substance

Product name: 2-Butanone
Synonyms: 2-butanone,MEK
CAS: 78-93-3
EC number: 201-159-0
MF: C4H8O
MW: 72.11

SECTION 4: First aid measures

Description of first aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Dry powder Dry sand

Unsuitable extinguishing media

Do NOT use water jet.

Special hazards arising from the substance or mixture

Carbon oxides

Flash back possible over considerable distance., Container explosion may occur under fire conditions.

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

Further information

Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas.

For personal protection see section 8.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Methods and materials for containment and cleaning up

Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local / national regulations (see section 13).

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.

Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Store under inert gas. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Store in cool place.

Hygroscopic. Store under nitrogen.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection

Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Splash contact Material: butyl-rubber

Minimum layer thickness: 0,3 mm Break through time: 292 min

Material tested:Butoject? (KCL 897 / Aldrich Z677647, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our

customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Impervious clothing, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Exposure limits

TLV-TWA, PEL 590 mg/m³ (200 ppm) (ACGIH, OSHA); STEL 885 mg/m³ (300 ppm) (ACGIH); IDLH 3000 ppm (NIOSH).

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearancecolourless liquid, clear
OdourNo data available
Odour Threshold0.44ppm
pHpH(1+4, 25℃):6.0～7.0
Melting point/freezing point-87 °C
Initial boiling point and boiling range80 °C - lit.
Flash point-3 °C - closed cup
Evaporation rateNo data available
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limitsUpper explosion limit: 10,1 %(V) Lower explosion limit: 1,8 %(V)
Vapour pressure95 hPa at 20 °C
Vapour density2,49 - (Air = 1.0)
Relative density0,805 g/mL at 25 °C
Water solubilitysoluble
Partition coefficient: n-octanol/waterlog Pow: 0,29
Autoignition temperatureNo data available
Decomposition temperatureNo data available
ViscosityNo data available
Explosive propertiesNo data available
Oxidizing propertiesNo data available
Henry's Law Constant23.0 at 50.00 °C, 34.1 at 60.00 °C, 50.6 at 70.00 °C, 70.4 at 80.00 °C (headspace-GC, Hovorka et al., 2002)

Other safety information

Surface tension 24,6 mN/m at 20 °C

Relative vapour density

2,49 - (Air = 1.0)

SECTION 10: Stability and reactivity

Reactivity

No data available

Chemical stability

Stable under recommended storage conditions.

Possibility of hazardous reactions

No data available

Conditions to avoid

Exposure to moisture Heat, flames and sparks.

Incompatible materials

Oxidizing agents, Strong reducing agents

Hazardous decomposition products

Other decomposition products - No data available

Hazardous decomposition products formed under fire conditions. - Carbon oxides In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - 2.737 mg/kg
LC50 Inhalation - Mouse - 4 h - 32.000 mg/m3 LC50 Inhalation - Mammal - 38.000 mg/m3 LD50 Dermal - Rabbit - 6.480 mg/kg

Skin corrosion/irritation

Skin - Rabbit
Result: No skin irritation (OECD Test Guideline 404)

Serious eye damage/eye irritation

Eyes - Rabbit
Result: Irritating to eyes. (OECD Test Guideline 405)

Respiratory or skin sensitisation

No data available

Germ cell mutagenicity

No data available

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

May cause drowsiness or dizziness.

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

Additional Information

RTECS: EL6475000
Central nervous system depression, Gastrointestinal disturbance, narcosis
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Liver - Irregularities - Based on Human Evidence

Toxicity

LD50 orally in rats: 6.86 ml/kg (Smyth)

SECTION 12: Ecological information

Toxicity

Toxicity to fish

mortality NOEC - Cyprinodon variegatus (sheepshead minnow) - 400 mg/l - 96 h

LC50 - Pimephales promelas (fathead minnow) - 3.130 - 3.320 mg/l

- 96 h

Toxicity to daphnia and other aquatic invertebrates

LC50 - Daphnia magna (Water flea) - > 520 mg/l - 48 h

EC50 - Daphnia magna (Water flea) - 7.060 mg/l - 24 h

Persistence and degradability

No data available

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material

must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

Incompatibilities

Violent reaction with strong oxidizers, amines, ammonia, inorganic acids; caustics, isocyanates, pyridines. Incompatible with potassium tert-butoxide, 2-propanol, chlorosulfonic acid; oleum.

Waste Disposal

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration

Contaminated packaging

Dispose of as unused product.

SECTION 14: Transport information

UN number

ADR/RID: 1193 IMDG: 1193 IATA: 1193

UN proper shipping name

	ADR/RID: ETHYL METHYL KETONE IMDG: ETHYL METHYL KETONE
IATA: Ethyl methyl ketone
14.3	Transport hazard class(es) ADR/RID: 3 IMDG: 3	IATA: 3
14.4	Packaging group ADR/RID: II IMDG: II	IATA: II
14.5	Environmental hazards ADR/RID: no IMDG Marine pollutant: no	IATA: no
14.6	Special precautions for user No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

EC Inventory:Listed.

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

SECTION 16: Other information

Abbreviations and acronyms

ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
CAS: Chemical Abstracts Service
EC50: Effective Concentration 50%
IATA: International Air Transportation Association
IMDG: International Maritime Dangerous Goods
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
STEL: Short term exposure limit
TWA: Time Weighted Average

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

The odour warning when the exposure limit value is exceeded is insufficient.

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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