BDO (1,4-Butanediol)

CAS

Purity

CHARACTER

1,4-Butanediol (BDO) is an important organic chemical and fine chemical raw materials, chemical formula is C4H10O2, molecular weight 90.12. Its appearance is colorless or pale yellow oily liquid, soluble in methanol, ethanol, acetone, slightly soluble in ether, miscible with water. 1,4-Butanediol is widely used in the manufacture of polybutylene terephthalate (PBT), polytetramethylene ether glycol (PTMEG), tetrahydrofuran (THF) and polyurethane, etc. It is the basic raw material for the production of high-performance plastics and high-elasticity spandex (Lycra fiber). In addition, it is also used in the preparation of vitamin B6, drugs, pesticides, herbicides and a variety of process solvents, plasticizers, lubricants, moisturizers and so on. As a multifunctional chemical raw material, 1,4-butanediol plays an important role in many industrial fields.

APPLICATIONS

(1) Polyester and polyurethane production: 1,4-Butanediol is the key raw material for the production of polybutylene terephthalate (PBT) and polyurethane (PU). PBT is a thermoplastic with excellent mechanical properties and chemical resistance. It is widely used in electronic appliances, auto parts and mechanical equipment; PU is widely used in foam plastics, elastomers, fibers and coatings.

(2) Drug synthesis: 1,4-Butanediol is an intermediate of many drugs and plays a key role in the synthesis of antibiotics, antidepressants, antihistamines, as well as vitamin B6 and some anticancer drugs.

(3) Humectants and solvents: 1,4-Butanediol is often used as a humectant and solvent in cosmetics due to its good moisturizing properties and solubility, and is used in the manufacture of facial masks, shampoos, hair conditioners and other products.

(4) Plasticizer and chain extender: It can also be used as a plasticizer and chain extender for the production of polyurethane, epoxy resin, unsaturated polyester and other polymer materials.

(5) Raw materials for fiber products: 1,4-Butanediol can be used to manufacture fiber products such as artificial silk and artificial cotton, providing important raw materials for the textile industry.

(6) Pesticide production: It can also be used as a raw material for pesticides and herbicides and play a role in agricultural production.

(7) Production of high value-added chemicals: 1,4-Butanediol can also be used to produce chemical products such as tetrahydrofuran (THF), gamma-butyrolactone (GBL) and N-methylpyrrolidone (NMP). These compounds also occupy an important position in their respective application fields.

INDICATORS

ABILITIES

1. Packing: barreled, scattered water
2. Logistics: car transportation, shipping
3. Payment request: EXW/FOB/FCA/CFR only accepted

HONORARY

Chinese name	1,4-Butanediol
English Name	1,4-Butanediol
Alias	Butanediol 4-Butanediol 1,4-Butanediol 4-Dihydroxybutane 1,4-Dihydroxybutane 1,4-Butanediol AR 1,4-Butanediol Standard 1,4-Butanediol (1,4-Dihydroxybutane)
English alias	BDO 1,4-Butanediol 1,4-BUTANEDIOL butane-1,4-diol butane-1,1-diol BUTANEDIOL, 1,4- AKOS BBS-00004303 1,4-DIHYDROXYBUTANE 1,4-BUTYLENE GLYCOL 1,4-Butylene glycol TETRAMETHYLENE GLYCOL Tetramethylene glycol VERSALINK CURATIVE 1,4 BDO
CAS	110-63-4
EINECS	203-786-5
Chemical formula	C4H10O2
molecular weight	90.12
InChI	InChI=1/C4H10O2/c5-3-1-2-4-6/h5-6H,1-4H2
InChIKey	WERYXYBDKMZEQL-UHFFFAOYSA-N
Density	1.017 g/mL at 25°C (lit.)
Melting Point	16°C (lit.)
Boiling Point	230°C (lit.)
Flash Point	135°C
water soluble	Miscible
steam density	3.1 (vs air)
Solubility	Slightly soluble in ether, miscible with water, soluble in ethanol, etc.
refractive index	n20/D 1.445(lit.)
acidity coefficient	14.73±0.10(Predicted)
PH value	7-8 (500g/l, H2O, 20℃)
Storage conditions	Store below +30°C.
Stability	Stable. Combustible. Incompatible with strong oxidants, inorganic acids, acid chlorides and acid anhydrides.
Sensitivity	Hygroscopic
Appearance	Solid
Color	Clear colorless
Smell	Odorless
BRN	1633445
Explosion limit value	1.95-18.3%(V)
physicochemical properties	Colorless oily liquid. Miscible with water. Soluble in methanol, ethanol, acetone, slightly soluble in ether.
MDL No.	MFCD00002968
Dangerous Goods Signs	Xn -of Hazardous Items
Risk Terms	R22-Harmful if swallowed. R67-Vapor may cause drowsiness and dizziness.
Safety terminology	S36-Wear suitable protective clothing. S23-Do not inhale vapors. S24/25-Avoid contact with skin and eyes.
WGK Germany	1
RTECS	EK0525000
TSCA	Yes
Customs Number	29053980
Upstream raw materials	Formaldehyde Acetylene
Downstream Products	2,3-Dihydrofuran γ-butyrolactone polyurethane resin polyvinylpyrrolidone

1,4-Butanediol- Properties

Colorless oily liquid, flammable, miscible with water. Soluble in methanol, ethanol, acetone, slightly soluble in ether. Boiling point 228 ℃. Melting point 20.2 ℃. Flash point (open cup) 121 ℃. Relative density of 1. 0171. Refractive index 1. 4461.

1,4-Butanediol- Preparation method

The acetylene method first reacts acetylene and formaldehyde in the presence of a Cu-Bi catalyst at 98kPa and 80-95°C to prepare 1,4-butynediol. The latter is catalyzed by skeleton nickel, hydrogenated at 1.372~2.06 MPa, 50~60 ℃ to 1,4-butenediol, followed by Ni-Cu- Mn/Al2 03 further catalytic hydrogenation (13.7 ~ 20.6MPa, 120~140 ℃) to 1,4-butanediol, removed by ion exchange resin after metal ions, and then purified by distillation.
Butadiene method by 1,3 butadiene and acetic acid and oxygen for acetylation oxidation reaction, generating 1,4-= acetoxy-2-butene, and then by hydrogenation, hydrolysis.

1,4-Butanediol- Introduction

Combustible. The taste is bitter. Can be miscible with water, soluble in alcohol, slightly soluble in ether. In the coolant solidification into colorless needle-like crystals, and dilute nitric acid reaction to succinic acid, potassium carbonate solution to produce precipitation

1,4-Butanediol- Uses

Mainly used in the manufacture of tetrahydrofuran, y-butyrolactone, polyurethane and thermoplastic engineering plastics PBT resin. It can also prepare N-methyl pyrrolidone, N-vinyl pyrrolidone and other pyrrolidone derivatives, and is also used in the preparation of vitamin B6, pesticides, herbicides, and as solvents, plasticizers, lubricants, moisturizers, softeners, adhesives and brighteners for the electroplating industry.

1,4-Butanediol- Safety

Toxic. When attached to diseased or injured skin or when drinking, it will initially present anesthesia, causing special pathological changes in the liver and kidneys, and then sudden death due to central nerve paralysis (without prolonged latency). Rat oral LD 50 210~420 mg/kg. Production equipment shall be sealed to prevent leakage, and operators shall wear protective equipment. People with skin trauma are strictly prohibited from contact with this product.
Aluminum, stainless steel, galvanized iron drums or plastic drums shall be used for packaging, or tankers shall be used for storage and transportation in accordance with regulations on inflammable and toxic substances. Because the melting point is as high as 20 ℃, the tank car should be equipped with heating pipes.

1,4-Butanediol- Introduction

1,4-Butanediol (also known as butanediol or 1,4-butanediol) is an organic compound. It is a colorless, odorless liquid, viscous at room temperature.

1,4-butanediol has many important properties and applications. It is a solvent with good solubility and plays an important role in the synthesis of many organic compounds. Secondly, 1,4-butanediol has a bis-alcohol nature and can undergo a variety of reactions, such as esterification, oxidation, etherification and the like. This makes it widely used in the synthesis of polyesters, polyethers, plastics, coatings, adhesives and dyes. A common process for the preparation of 1,4-butanediol

is by the oxidation of n-butane. This reaction usually needs to be carried out at a high temperature in the presence of an oxidizing agent such as oxygen, and the presence of a catalyst is used to increase the reaction rate.
it is a combustible substance that can produce flammable vapors. Contact with open flames, high temperatures and sources of open flames should be avoided during handling. 1,4-Butanediol may also be irritating to the skin and eyes. Wear protective glasses and gloves when handling. In the event of an accident, rinse the affected area immediately with plenty of water and consult a doctor.

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Chemical Safety Data Sheet MSDS / SDS

1,4-Butanediol

Revision Date:2024-10-26Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: 1,4-Butanediol
CBnumber: CB4452184
CAS: 110-63-4
EINECS Number: 203-786-5
Synonyms: BDO,Butylene Glycol

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Shanghai Skyseven Chemicals Co.,Ltd
Address: 9F,Block B ,WOLI Center, Lane 2157, Hu Nan Road, Pudong New District, Shanghai, China
Telephone: 86-21-5017-9788

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordWarning

Precautionary statements

P330 Rinse mouth.

P270 Do not eat, drink or smoke when using this product.

P264 Wash skin thouroughly after handling.

P264 Wash hands thoroughly after handling.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

Hazard statements

H336 May cause drowsiness or dizziness

H302 Harmful if swallowed

SECTION 3: Composition/information on ingredients

Substance

Product name: 1,4-Butanediol
Synonyms: BDO,Butylene Glycol
CAS: 110-63-4
EC number: 203-786-5
MF: C4H10O2
MW: 90.12

SECTION 4: First aid measures

Description of first aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Flush eyes with water as a precaution.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

Carbon oxides

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

Further information

No data available

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation.

For personal protection see section 8.

Environmental precautions

Do not let product enter drains.

Methods and materials for containment and cleaning up

Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Store in cool place.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection

Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Full contact

Material: Nitrile rubber

Minimum layer thickness: 0,11mm Break through time: 480 min

Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M)

Splash contact Material: Nitrile rubber

Minimum layer thickness: 0,11mm Break through time: 480 min

Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure

Do not let product enter drains.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearancecolourless viscous
OdourNo data available
Odour ThresholdNo data available
pH7-8 (500g/l, H2O, 20℃)
Melting point/freezing pointMelting point/range: 16°C - lit.
Initial boiling point and boiling range230 °C - lit.
Flash point134 °C - closed cup
Evaporation rateNo data available
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limits1.95-18.3%(V)
Vapour pressure0,019 hPa at 25°C - OECD Test Guideline 104
Vapour density3,11 - (Air = 1.0)
Relative density1,017 g/cm3 at 25°C - lit.
Water solubility100 g/l at 25°C - OECD Test Guideline 105 - completely miscible
Partition coefficient: n-octanol/waterlog Pow: -0,88 at 25°C - OECD Test Guideline 107
Autoignition temperature385 °C at 1.013 hPa
Decomposition temperatureNo data available
Viscosity83,2 mm2/s at 20°C-
Explosive propertiesNo data available
Oxidizing propertiesNo data available

Other safety information

Dissociation constant 14,5

Relative vapour density

3,11 - (Air = 1.0)

SECTION 10: Stability and reactivity

Reactivity

No data available

Chemical stability

Stable under recommended storage conditions.

Possibility of hazardous reactions

No data available

Conditions to avoid

No data available

Incompatible materials

Strong oxidizing agents, Acid chlorides, Acid anhydrides, Reducing agents

Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - No data available

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - male and female - 1.500 mg/kg
LC50 Inhalation - Rat - male and female - 4 h - > 5,1 mg/l (OECD Test Guideline 403)
LD50 Dermal - Rat - male and female - > 5.000 mg/kg

Skin corrosion/irritation

Skin - Rabbit
Result: No skin irritation - 24 h

Serious eye damage/eye irritation

Eyes - Rabbit
Result: No eye irritation

Respiratory or skin sensitisation

Maximisation Test - Guinea pig
Result: Does not cause skin sensitisation.

Germ cell mutagenicity

In vitro mammalian cell gene mutation test Chinese hamster ovary cells
Result: negative

Carcinogenicity

IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

May cause drowsiness or dizziness.

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

Additional Information

Repeated dose toxicity - Rat - male and female - Oral - No observed adverse effect level - 50 mg/kg - Lowest observed adverse effect level - 500 mg/kg
RTECS: Not available
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Toxicity

LD50 orally in Rabbit: 1525 mg/kg LD50 dermal Rabbit > 2000 mg/kg

SECTION 12: Ecological information

Toxicity

Toxicity to fish

static test LC50 - Pimephales promelas (fathead minnow) - > 30.000 mg/l - 96 h

(OECD Test Guideline 203)

Toxicity to daphnia and other aquatic invertebrates

static test EC50 - Daphnia magna (Water flea) - 813 mg/l - 48 h (OECD Test Guideline 202)

Toxicity to algae

static test EC50 - Desmodesmus subspicatus (green algae) - > 500 mg/l - 72 h

Persistence and degradability

Biodegradability aerobic - Exposure time 10 d

Result: 90 - 100 % - Readily biodegradable. (OECD Test Guideline 302B)

Bioaccumulative potential

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

Contaminated packaging

Dispose of as unused product.

SECTION 14: Transport information

UN number

ADR/RID: - IMDG: - IATA: -

UN proper shipping name

ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA: Not dangerous goods

Transport hazard class(es)

ADR/RID: - IMDG: - IATA: -

Packaging group

ADR/RID: - IMDG: - IATA: -

Environmental hazards

ADR/RID: no IMDG Marine pollutant: no IATA: no

Special precautions for user

No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Not Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

EC Inventory:Listed.

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

[1] CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

[2] ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

[3] ECHA-European Chemicals Agency, website: https://echa.europa.eu/

[4] eChemPortal-The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

[5] ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

[6] Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

[7] HSDB-Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

[8] IARC-International Agency for Research on Cancer, website: http://www.iarc.fr/

[9] IPCS-The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

[10] Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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