BPA (Bisphenol A)

CAS

Purity

CHARACTER

bisphenol A(BPA), chemical formula C15H16O2, is an important organic compound with a molecular weight of 228.29. It appears as white needle-like crystals or powder, insoluble in water, but soluble in organic solvents such as acetone. Bisphenol A is a key raw material for the manufacture of polymer materials such as polycarbonate, epoxy resin, etc. These materials are widely used in the manufacturing process of plastic tableware, toys, spectacle lenses, sports helmets, electrical product shells and the inner peritoneum of cans. Bisphenol A can make the product have the characteristics of light weight, high temperature resistance, drop resistance and corrosion resistance, and prolong the service life. However, it should be noted that bisphenol A may have a certain impact on human health. Therefore, it has been banned in some countries and regions in specific products such as infant bottles.

APPLICATIONS

(1) One of the main uses of bisphenol A(BPA) in the chemical industry is to produce polycarbonate (PC) plastics and epoxy resins. These plastics are widely used in the manufacture of various products because of their high transparency, durability and portability.

(2) BPA is also used in the manufacture of food and beverage containers, such as plastic water bottles, baby bottles and food storage containers. In addition, it is also used in the production of certain medical devices, such as syringes and blood containers, because these products need to be transparent and resistant to chemicals.

(3) In the manufacture of electronic products, bisphenol A is used to produce plastic parts such as optical discs, eyeglass lenses and mobile phone cases. At the same time, it is also used as the internal coating of metal cans to prevent direct contact between metal and food and avoid corrosion.

(4) Bisphenol A is also an important organic synthetic raw material, which can be used to produce fine chemical products such as plasticizers, flame retardants, antioxidants, heat stabilizers, rubber antioxidants, pesticides and coatings.

ABILITIES

1. Packing: barreled, scattered water
2. Logistics: car transportation, shipping
3. Payment request: EXW/FOB/FCA/CFR only accepted

HONORARY

Chinese name	Bisphenol A
English Name	4,4'-Isopropylidenediphenol
Alias	Bisphenol A diphenol propane 2,2-Diphenol Propane 2,2-di-p-phenol propane 2,2-Bis-p-hydroxyphenylpropane 4,4 'dihydroxydiphenylpropane 2,2-Bis (4-hydroxyphenyl) propane 2,2-Bis (4-hydroxyphenyl) propane 4,4 '-(1-Methylethylene) bisphenol 4,4 '-(1-Methylethylene) bisphenol 2,2-(4,4-Dihydroxydiphenylpropane) 2,2-Bis (4-hydroxyphenyl) propane (bisphenol A)
English alias	BPA Bisphenol-A Bisphenol A diphenylolpropane 4,4'-Isopropylidenediphenol 2,2-Bis(hydroxyphenyl)propane 2,2-Bis(4-hydroxyphenyl)-propa 2,2-Bis(4-hydroxyphenyl)propane 2,2-Bis (4-hydroxyphenol) propane Tetrabromobisphenol A Allyl Ether 4,4'-(1-Methylethylidene)bisphenol 2,2-Bis(4,4'-hydroxyphenyl)propane 4,4'-(1-methylethylidene)bisphenol 4,4'-(1-methylethylidene)bis-pheno 4,4'-(1-methylethylidene)bis-Phenol
CAS	80-05-7
EINECS	201-245-8
Chemical formula	C15H16O2
molecular weight	228.29
InChI	InChI=1/2C6H6O2.C3H8/c27-5-1-2-6(8)4-3-5;1-3-2/h21-4,7-8H;3H2,1-2H3
InChIKey	IISBACLAFKSPIT-UHFFFAOYSA-N
Density	1.195
melting point	158-159°C(lit.)
Boiling Point	220°C4mm Hg(lit.)
Flash Point	227°C
water solubility	<0.1 g/100 mL at 21.5°C
Vapor pressure	<1 Pa (25°C)
solubility	0.12g/l insolubles
refractive index	1.5542 (estimate)
acidity coefficient	10.29±0.10(Predicted)
Storage conditions	Store below +30°C.
Appearance	Solid
Color	Clear light yellow to light orange
Smell	Phenol like
Merck	14,1297
BRN	1107700
physicochemical properties	white needle crystal or flake powder. Microstrip phenol odor. Soluble in ethanol, acetone, ether, benzene and dilute alkali, slightly soluble in carbon tetrachloride, almost insoluble in water.
MDL No.	MFCD00002366
Dangerous Goods Signs	Xn-Hazardous Items
Risk Terms	R37-Stimulation of respiratory system. to R41-serious eye injury. , R43-Skin contact may cause sensitization. , R62-Risk of impaired fertility. , R52-Harmful to aquatic life.
Safety terminology	S26-After eye contact, rinse immediately with plenty of water and seek medical advice. -S36/37/39-Wear appropriate protective clothing, gloves and goggles or masks. -S45-In case of accident or feeling unwell, seek medical attention (if possible, show their label). -S46-If swallowed, seek medical advice immediately and show the container or label. , S39-Wear goggles or mask. , S36/37-Wear appropriate protective clothing and gloves. S61-Avoid release to environment. Refer to Special Instructions/Safety Data Sheet.
Dangerous Goods Transport Number	UN 3077 9 / PGIII
WGK Germany	2
RTECS	SL6300000
TSCA	Yes
Customs Number	29072300
Upstream raw materials	Sulfuric acid acetone phenol polycarbonate dissolving kettle 2,4 '-isopropylidenediphenol
Downstream Products	bisphenol A type diether dianhydride polycarbonate phenolic resin tetrabromobisphenol A

Bisphenol A -Properties

white needle crystal or flake powder. Combustible. Microstrip phenol odor. Boiling point 250~252 ℃. The melting point of the pure product is 155~158 ℃. Industrial melting point 150 N152. Relative density 1.195, flash point 79.4 ℃. Soluble in ethanol, acetone, ether, benzene and dilute alkali, slightly soluble in carbon tetrachloride, almost insoluble in water.

Bisphenol A -process

phenol and acetone are condensed in the presence of a catalyst, washed with water, crystallized and filtered to obtain a crude product. After recrystallization, centrifugal separation and drying, the finished product is obtained.

Bisphenol A -Introduction

has a slight smell of phenol. Decomposition at about 260°C. It's irritating.

Bisphenol A -Uses

Used in the manufacture of a variety of polymer materials, such as epoxy resin, polycarbonate, polysulfone and phenolic unsaturated resin. It is also used in the manufacture of PVC heat stabilizers, rubber antioxidants, agricultural fungicides, paints, inks, antioxidants and plasticizers.

Bisphenol A -Safety

is less toxic than phenols and is a low-toxic substance. Rats oral LD50 4200 mg/kg. When poisoning will feel bitter mouth, headache, on the skin, respiratory tract, corneal irritation symptoms. Operators should wear protective equipment, production equipment should be closed, the operation site should be well ventilated.
The shall be packed in wooden barrels, iron barrels or sacks lined with plastic bags, with a net weight of 25kg or 30kg per barrel (bag). Fireproof, waterproof and explosion-proof during storage and transportation. It should be placed in a dry and ventilated place. Storage and transportation shall be in accordance with general chemical regulations.

Bisphenol A -Introduction

Bisphenol A (Bisphenol A, BPA) is an organic compound. Bisphenol A is a colorless to yellowish solid, soluble in organic solvents such as ketones and esters. A common method for preparing bisphenol A

is by condensation of a phenol and an aldehyde, typically using an acidic catalyst. It is necessary to control the reaction conditions and the choice of catalyst in the preparation process to obtain high purity bisphenol A product.

Safety Information: Bisphenol A is considered to have certain toxicity and potential environmental hazards. Studies have shown that bisphenol A may interfere with the endocrine system and is considered to have adverse effects on the reproductive system, nervous system and immune system. Long-term exposure to BPA may negatively affect the development of infants and children.

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Chemical Safety Data Sheet MSDS / SDS

Bisphenol A

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: Bisphenol A
CBnumber: CB5854419
CAS: 80-05-7
EINECS Number: 201-245-8
Synonyms: BPA,bisphenol A

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P405 Store locked up.

P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P273 Avoid release to the environment.

P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

P201 Obtain special instructions before use.

Hazard statements

H411 Toxic to aquatic life with long lasting effects

H361 Suspected of damaging fertility or the unborn child

H335 May cause respiratory irritation

H318 Causes serious eye damage

H317 May cause an allergic skin reaction

Disposal

WARNING.Cancer - https://oehha.ca.gov/proposition-65/chemicals/bisphenol-bpa

SECTION 3: Composition/information on ingredients

Substance

Product name: Bisphenol A
Synonyms: BPA,bisphenol A
CAS: 80-05-7
EC number: 201-245-8
MF: C15H16O2
MW: 228.29

SECTION 4: First aid measures

Description of first aid measures

General advice

Consult a physician. Show this material safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed

Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

Carbon oxides

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

Further information

No data available

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up

Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Advice on safe handling

Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Advice on safe

handling

Avoid exposure - obtain special instructions before use.

Advice on protection against fire and explosion

Provide appropriate exhaust ventilation at places where dust is formed.

Hygiene measures

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Storage conditions

Keep container tightly closed in a dry and well-ventilated place. Store in cool place.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Personal protective equipment

Eye/face protection

Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Full contact

Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 480 min

Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M)

Splash contact Material: Nitrile rubber

Minimum layer thickness: 0,11 mm Break through time: 480 min

Material tested:Dermatril? (KCL 740 / Aldrich Z677272, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full- face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure

Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearancebeige crystalline
Odourodorless
Odour ThresholdNo data available
pHNo data available
Melting point/freezing pointMelting point/range: 158 - 159 °C - lit.
Initial boiling point and boiling range220 °C at 5 hPa - lit.
Flash point227 °C at ca.1.013 hPa - closed cup
Evaporation rateNo data available
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limitsNo data available
Vapour pressure<1 Pa (25 °C)
Vapour densityNo data available
Relative density1,2 g/cm3 at 25 °C No data available
Water solubility0,298 g/l at 25 °C - OECD Test Guideline 105- soluble
Partition coefficient: n-octanol/waterlog Pow: 3,4 at 21,5 °C - Bioaccumulation is not expected.
Autoignition temperature510 °C at 1.013 hPa
Decomposition temperatureNo data available
ViscosityViscosity, kinematic: No data available Viscosity, dynamic: No data available
Explosive propertiesNo data available
Oxidizing propertiesNo data available

Other safety information

Dissociation constant >= 11,3

SECTION 10: Stability and reactivity

Reactivity

No data available

Chemical stability

Stable under recommended storage conditions.

Possibility of hazardous reactions

No data available

Conditions to avoid

No data available

Incompatible materials

Strong bases, Strong oxidizing agents

Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - male and female - > 2.000 - 5.000 mg/kg (OECD Test Guideline 401)
LC50 Inhalation - Rat - male and female - 6 h - 17 mg/l Remarks: (ECHA)
Inhalation: Irritating to respiratory system. LD50 Dermal - Rabbit - 6.400 mg/kg Remarks: (ECHA)

Skin corrosion/irritation

Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)

Serious eye damage/eye irritation

Eyes - Rabbit
Result: Causes serious eye damage. (OECD Test Guideline 405)
Remarks: (Regulation (EC) No 1272/2008, Annex VI)

Respiratory or skin sensitization

Human experience Result: positive
Remarks: (External MSDS)

Germ cell mutagenicity

Test Type: Ames test
Test system: Escherichia coli/Salmonella typhimurium Metabolic activation: with and without metabolic activation Result: negative
Test Type: Mutagenicity (mammal cell test): chromosome aberration. Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation Result: negative
Remarks: (ECHA)
Test Type: In vitro mammalian cell gene mutation test Test system: Mouse lymphoma test
Metabolic activation: with and without metabolic activation Result: negative
Remarks: (ECHA)
Test Type: In vivo micronucleus test Species: Mouse
Cell type: Bone marrow Application Route: Oral
Result: negative Remarks: (ECHA)

Carcinogenicity

No data available

Reproductive toxicity

May damage fertility.

Specific target organ toxicity - single exposure

Inhalation - May cause respiratory irritation. - Respiratory system

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

Toxicity

LC50 (96 hr) in fathead minnow, rainbow trout: 4600, 3000-3500 mg/l (Staples)

SECTION 12: Ecological information

Toxicity

Toxicity to fish

flow-through test LC50 - Pimephales promelas (fathead minnow) - 4,6 mg/l - 96 h

(OECD Test Guideline 203)

flow-through test LC50 - Cyprinodon variegatus (sheepshead minnow) - 11 mg/l - 96 h

(OECD Test Guideline 203)

Toxicity to daphnia and other aquatic invertebrates

static test EC50 - Daphnia magna (Water flea) - 10,2 mg/l - 48 h Remarks: (ECHA)

Toxicity to algae

static test ErC50 - Pseudokirchneriella subcapitata (green algae) - 2,73 - 3,1 mg/l - 96 h

(US-EPA)

Toxicity to bacteria

EC50 - activated sludge - 58,4 mg/l - 3 h

Remarks: (External MSDS)

Persistence and degradability

Biodegradability aerobic - Exposure time 28 d

Result: 89 % - Readily biodegradable. (OECD Test Guideline 301F)

Bioaccumulative potential

Bioaccumulation Cyprinus carpio (Carp) - 42 d

(4,4'-isopropylidenediphenol)

Bioconcentration factor (BCF): 5,1 - 13,3 (MITI test)

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

Toxic to aquatic life with long lasting effects.

SECTION 13: Disposal considerations

Waste treatment methods

Product

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Offer surplus and non-recyclable solutions to a licensed disposal company. Waste material must be disposed of in accordance with the Directive on waste 2008/98/EC as well as other national and local regulations. Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, acid chlorides and acid anhydrides.

Contaminated packaging

Dispose of as unused product.

SECTION 14: Transport information

UN number

ADR/RID: 3077 IMDG: 3077 IATA: 3077

UN proper shipping name

ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (4,4'-

isopropylidenediphenol)

IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (4,4'-

isopropylidenediphenol)

IATA: Environmentally hazardous substance, solid, n.o.s. (4,4'-isopropylidenediphenol)

Transport hazard class(es)

ADR/RID: 9 IMDG: 9 IATA: 9

Packaging group

ADR/RID: III IMDG: III IATA: III

Environmental hazards

ADR/RID: yes IMDG Marine pollutant: yes IATA: yes

Special precautions for user

Further information

EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids.Packages smaller than or equal to 5 kg / L , not dangerous goods of Class 9

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Not Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

EC Inventory:Listed.

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

SECTION 16: Other information

Abbreviations and acronyms

ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
CAS: Chemical Abstracts Service
EC50: Effective Concentration 50%
IATA: International Air Transportation Association
IMDG: International Maritime Dangerous Goods
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
STEL: Short term exposure limit
TWA: Time Weighted Average

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Other Information

The substance is absorbed through the skin but no toxic effects were reported (2011)

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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