DMC (dimethyl carbonate)

CAS

Purity

CHARACTER

dimethyl carbonate (DMC), chemical formula C3H6O3, is a colorless transparent liquid, with a weak ester odor, slightly soluble in water, soluble in ethanol, ether and other organic solvents. Dimethyl carbonate is an important organic chemical raw material and green solvent, which is widely used in the fields of medicine, pesticide, dye, paint and synthesis gas. In pharmaceutical manufacturing, it is used as a synthetic raw material for the preparation of a variety of drugs; in the pesticide industry, dimethyl carbonate is used for the synthesis of pesticides and herbicides; in addition, it is also an important solvent for the synthesis of dyes and coatings to improve the solubility of products And stability; in the field of synthesis gas, dimethyl carbonate has broad application prospects as a hydrogen source for fuel cells. As a multifunctional organic compound, dimethyl carbonate has been widely used in many industrial fields.

APPLICATIONS

(1) Dimethyl carbonate (DMC) is used as a methylating agent and carbonylating agent in chemical synthesis, which can be used in the preparation of pesticides and herbicides, and the synthesis of various carbamate pesticides, such as carbaryl. At the same time, it can also be used for non-phosgene synthesis of polycarbonate, diphenyl carbonate, isocyanate and allyl diglycol carbonate and other organic compounds.

(2) Dimethyl carbonate (DMC) is an important organic synthesis intermediates, which can be used for the synthesis of anisole, benzene dimethyl ether, alkyl aromatic amines, symmetrical carbazide, methyl formate and other organic compounds, as well as the preparation of amino oxazolidinone, ciprofloxacin, β-ketocarboxylate pharmaceutical intermediates and other pharmaceutical products.

(3) As a solvent, dimethyl carbonate (DMC) has excellent solubility and polarity. It is an ideal solvent for many organic compounds. It can be used as a diluent for resins, coatings, rubber, and as a fuel such as gasoline and lubricating oil. Additives to improve fuel performance and stability.

(4) Dimethyl carbonate (DMC) can also be used for the cleaning of medical equipment, with good cleaning ability. At the same time, it can also be used as a thickener to thicken and stabilize various foods and beverages, increase the taste and quality of foods and beverages, and extend their shelf life.

INDICATORS

ABILITIES

1. Packing: barreled, scattered water
2. Logistics: car transportation, shipping
3. Payment request: EXW/FOB/FCA/CFR only accepted

HONORARY

Chinese name	dimethyl carbonate
English Name	Dimethyl carbonate
Alias	Methyl carbonate ethane carbonate dimethyl carbonate methyl (II) carbonate dimethyl carbonate (DMC) SOLIFENACIN related compounds 12 dimethyl carbonate, ultra-dry solvent, WATER ≤ 20 PPM, J & KSEAL bottle
English alias	DMC Methyl carbonate METHYL CARBONATE dimetyl carbonate DIMETHYL CARBONATE Dimethyl carbonate methylcarbonate((meo)2co) Carbonic acid dimethyl ester CARBONIC ACID DIMETHYL ESTER DIMETHYL CARBONATE, ANHYDROUS DimethylCarbonateForSynthesis DIMETHYL CARBONATE, REAGENTPLUS
CAS	616-38-6
EINECS	210-478-4
Chemical formula	C3H6O3
molecular weight	90.08
InChI	InChI=1/C3H6O3/c1-5-3(4)6-2/h1-2H3
InChIKey	IEJIGPNLZYLLBP-UHFFFAOYSA-N
Density	1.069 g/mL at 25°C (lit.)
Melting Point	2-4°C (lit.)
Boiling Point	90°C (lit.)
Flash Point	65 °F
water soluble	139 g/L
Vapor pressure	18mm Hg ( 21.1 °C)
steam density	3.1 (vs air)
Solubility	139g/l
refractive index	n20/D 1.368(lit.)
Storage conditions	Store below +30°C.
Stability	Stable. Highly flammable. Incompatible with potassium tert-butoxide, a strong oxidant.
Sensitivity	Moisture Sensitive
Appearance	Solid
Color	<50(APHA)
Smell	Pleasant
Merck	14,3241
BRN	635821
Explosion limit value	4.22-12.87%(V)
physicochemical properties	Colorless transparent liquid with pungent odor. Insoluble in water, soluble in ethanol, ether and other organic solvents.
Dangerous Goods Signs	F-Inflammable materials
Risk Terms	11-Highly flammable.
Safety terminology	S9-Keep the container in a well-ventilated place. S16-Keep away from sources of ignition. S2017/9/16-
Dangerous Goods Transport No.	UN 1161 3/PG 2
WGK Germany	1
RTECS	FG0450000
TSCA	Yes
Customs Number	2920 90 10
Hazard Class	3
Packing Group	II
Upstream raw materials	Propylene Oxide Methanol Propylene Carbonate
Downstream Products	Diethyl carbonate Methyl ethyl carbonate Sulfonate Ciprofloxacin

Nature

Colorless transparent liquid with pungent odor. Relative density 1.073. Melting point 2~4 ℃. Boiling point 90.2 ℃. Refractive index 1. 3697. Flash point (open cup) 21.7 ℃. Viscosity 0.664mPa.s. Insoluble in water, soluble in ethanol, ether and other organic solvents.

preparation method

Dimethyl carbonate can be produced by transesterification of ethylene carbonate or propylene carbonate with methanol. This method has high yield, low equipment corrosion and mild reaction conditions, but the source of raw materials is restricted by the development of petrochemical industry and the utilization rate of elements is low.
Oxidative carbonylation of methanol, carbon monoxide and oxygen in the direct synthesis of dimethyl carbonate catalyst. This method is cheap and easy to get raw materials, small toxicity, simple process, is the most promising method. According to the process conditions, it can be divided into liquid phase method and gas phase method, and the gas phase method can be divided into one-step method and two-step method. Among them, the two-step method of methanol liquid-phase oxidative carbonylation and gas-phase oxidative carbonylation has been industrialized, while the one-step method of methanol gas-phase oxidative carbonylation is still under development.
Methanol and CO2 reaction synthesis method
methanol and urea reaction synthesis method

Use

Dimethyl carbonate can replace the traditional use of toxic raw materials such as phosgene, dimethyl sulfate and methyl chloride. It can be used to synthesize polycarbonate, diphenyl carbonate, isocyanate and allyl diglycol carbonate by non-phosgene method. Used to synthesize various carbamate pesticides, such as carbaryl, etc. Organic synthesis intermediates, such as anisole, benzene dimethyl ether, alkyl aromatic amine, symmetrical disemicarbazide, methyl carbazate, etc. In the pharmaceutical industry, it can be used to prepare amino oxazolidone, ciprofloxacin, p ketone carboxylic acid ester pharmaceutical intermediates, etc. In addition, it can also be used as an additive for gasoline and diesel, refrigerator oil and solvent.

Security

This product is a non-toxic chemical. On the eyes, skin, mucous membrane have mild irritation. The oral LD50 of rats was 6.4-12.8 g/kg. The raw material phosgene used in the phosgene process is highly toxic, and the equipment must be strictly sealed, ventilation must be strengthened, and operators must wear various protective equipment.
This product is packed in iron drums. This product is flammable, contact with the oxidant can cause combustion, should be stored in a cool and ventilated special warehouse, away from the source of fire. Prevent damage to the packaging container and leakage. It shall be stored and transported according to the regulations of flammable and toxic hazardous chemicals.

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Chemical Safety Data Sheet MSDS / SDS

Dimethyl carbonate

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: Dimethyl carbonate
CBnumber: CB8853983
CAS: 616-38-6
EINECS Number: 210-478-4
Synonyms: DMC,dimethyl carbonate

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

SECTION 2: Hazards identification

GHS Label elements, including precautionary statements

Symbol(GHS)

Signal wordDanger

Precautionary statements

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233 Keep container tightly closed.

P240 Ground/bond container and receiving equipment.

P241 Use explosion-proof electrical/ventilating/lighting/…/equipment.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313 IF exposed or concerned: Get medical advice/attention.

P370+P378 In case of fire: Use … for extinction.

P403+P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

P501 Dispose of contents/container to..…

Hazard statements

H225 Highly Flammable liquid and vapour

H361 Suspected of damaging fertility or the unborn child

SECTION 3: Composition/information on ingredients

Substance

Product name: Dimethyl carbonate
Synonyms: DMC,dimethyl carbonate
CAS: 616-38-6
EC number: 210-478-4
MF: C3H6O3
MW: 90.08

SECTION 4: First aid measures

Description of first aid measures

General advice

Consult a physician. Show this safety data sheet to the doctor in attendance.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.

In case of skin contact

Wash off with soap and plenty of water. Consult a physician.

In case of eye contact

Flush eyes with water as a precaution.

If swallowed

Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in section 11

Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media

Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from the substance or mixture

Carbon oxides

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

Further information

Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas.

For personal protection see section 8.

Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Methods and materials for containment and cleaning up

Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet- brushing and place in container for disposal according to local regulations (see section 13).

Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

Precautions for safe handling

Avoid inhalation of vapour or mist.

Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge.

For precautions see section 2.2.

Conditions for safe storage, including any incompatibilities

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Air sensitive.

Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

control parameter

Hazard composition and occupational exposure limits

Does not contain substances with occupational exposure limits.

Exposure controls

Appropriate engineering controls

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Personal protective equipment

Eye/face protection

Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

The selected protective gloves have to satisfy the specifications of Regulation (EU) 2016/425 and the standard EN 374 derived from it.

Full contact

Material: butyl-rubber

Minimum layer thickness: 0,3 mm Break through time: 480 min

Material tested:Butoject? (KCL 897 / Aldrich Z677647, Size M)

Splash contact Material: butyl-rubber

Minimum layer thickness: 0,3 mm Break through time: 480 min

Material tested:Butoject? (KCL 897 / Aldrich Z677647, Size M)

data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the CE approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Impervious clothing, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full- face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and

components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Control of environmental exposure

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Appearancecolourless liquid
OdourNo data available
Odour ThresholdNo data available
pHNo data available
Melting point/freezing pointMelting point/range: 2 - 4 °C - lit.
Initial boiling point and boiling range90 °C - lit.
Flash point16 °C - closed cup
Evaporation rateNo data available
Flammability (solid, gas)No data available
Upper/lower flammability or explosive limitsUpper explosion limit: 12,87 %(V) Lower explosion limit: 4,22 %(V)
Vapour pressure24 hPa at 21,1 °C
Vapour density3,11 - (Air = 1.0)
Relative density1,069 g/cm3 at 25 °C
Water solubility114,7 g/l at 20 °C - OECD Test Guideline 105 - completely soluble
Partition coefficient: n-octanol/waterlog Pow: 0,354 at 20 °C
Autoignition temperatureNo data available
Decomposition temperatureNo data available
ViscosityNo data available
Explosive propertiesNo data available
Oxidizing propertiesNo data available

Other safety information

Surface tension 31,92 mN/m

Relative vapour density

3,11 - (Air = 1.0)

SECTION 10: Stability and reactivity

Reactivity

No data available

Chemical stability

Stable under recommended storage conditions.

Possibility of hazardous reactions

No data available

Conditions to avoid

Heat, flames and sparks.

Incompatible materials

Oxidizing agents, Strong acids, Strong bases

Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides Other decomposition products - No data available

In the event of fire: see section 5

SECTION 11: Toxicological information

Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - male and female - > 5.000 mg/kg (OECD Test Guideline 401)
LC50 Inhalation - Rat - male and female - 4 h - > 5,36 mg/l (OECD Test Guideline 403)
LD50 Dermal - Rabbit - male and female - > 2.000 mg/kg

Skin corrosion/irritation

Skin - Rabbit
Result: No skin irritation (OECD Test Guideline 404)

Serious eye damage/eye irritation

Eyes - Rabbit
Result: No eye irritation

Respiratory or skin sensitisation

(OECD Test Guideline 406)

Germ cell mutagenicity

Result: negative

Carcinogenicity

No data available
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

Reproductive toxicity

No toxicity to reproduction

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

Additional Information

RTECS: FG0450000
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Toxicity

LD50 in rats (g/kg): 13.8 orally; 2.5 dermally; LC50 (4 hr) in rats (mg/l): 140 by inhalation (Ono)

SECTION 12: Ecological information

Toxicity

Toxicity to fish

flow-through test LC50 - Danio rerio (zebra fish) - > 100 mg/l - 96 h (OECD Test Guideline 203)

Toxicity to daphnia and other aquatic invertebrates

static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h (OECD Test Guideline 202)

Toxicity to algae

static test EC50 - Pseudokirchneriella subcapitata (green algae) - > 100 mg/l - 72 h

(OECD Test Guideline 201)

Persistence and degradability

Biodegradability aerobic - Exposure time 28 d

Result: 86 % - Readily biodegradable. (OECD Test Guideline 301C)

Bioaccumulative potential

No data available

Mobility in soil

No data available

Results of PBT and vPvB assessment

This substance/mixture contains no components considered to be either persistent, bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at levels of 0.1% or higher.

Other adverse effects

No data available

SECTION 13: Disposal considerations

Waste treatment methods

Product

Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company.

Contaminated packaging

Dispose of as unused product.

SECTION 14: Transport information

UN number

ADR/RID: 1161 IMDG: 1161 IATA: 1161

UN proper shipping name

	ADR/RID: DIMETHYL CARBONATE IMDG: DIMETHYL CARBONATE
IATA: Dimethyl carbonate
14.3	Transport hazard class(es) ADR/RID: 3 IMDG: 3	IATA: 3
14.4	Packaging group ADR/RID: II IMDG: II	IATA: II
14.5	Environmental hazards ADR/RID: no IMDG Marine pollutant: no	IATA: no
14.6	Special precautions for user No data available

SECTION 15: Regulatory information

Safety, health and environmental regulations/legislation specific for the substance or mixture

Regulations on the Safety Management of Hazardous Chemicals

China Catalog of Hazardous chemicals 2015:Listed. website: https://www.mem.gov.cn/

Measures for Environmental Management of New Chemical Substances

Chinese Chemical Inventory of Existing Chemical Substances (China IECSC):Listed. website: https://www.mee.gov.cn/

EC Inventory:Listed.

European Inventory of Existing Commercial Chemical Substances (EINECS):Listed. website: https://echa.europa.eu/

Korea Existing Chemicals List (KECL):Listed. website: http://ncis.nier.go.kr

New Zealand Inventory of Chemicals (NZIoC):Listed. website: https://www.epa.govt.nz/

Philippines Inventory of Chemicals and Chemical Substances (PICCS):Listed. website: https://emb.gov.ph/

United States Toxic Substances Control Act (TSCA) Inventory:Listed. website: https://www.epa.gov/

Vietnam National Chemical Inventory:Listed. website: https://chemicaldata.gov.vn/

SECTION 16: Other information

Abbreviations and acronyms

ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
CAS: Chemical Abstracts Service
EC50: Effective Concentration 50%
IATA: International Air Transportation Association
IMDG: International Maritime Dangerous Goods
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
STEL: Short term exposure limit
TWA: Time Weighted Average

References

【1】CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple

【2】ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp

【3】ECHA - European Chemicals Agency, website: https://echa.europa.eu/

【4】eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en

【5】ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg

【6】Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp

【7】HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm

【8】IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/

【9】IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home

【10】Sigma-Aldrich, website: https://www.sigmaaldrich.com/

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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